Fast Track – BIORXIV – Scancovid-19

SCANCOVID-19

Pesquisas registradas

Quantidade de submissão por data:

Meses	Quantidade
Março	128
Abril	94

Data	Quantidade
20/03/2020	132
27/03/2020	71
30/03/2020	15
01/04/2020	20
02/04/2020	1
03/04/2020	16
06/04/2020	22
09/04/2020	22
09/04/2020	3
10/04/2020	9
13/04/2020	38
15/04/2020	5
Total	332

Associação de termos - tokens

Porcentagem da associação de termos presentes nos resumos dos artigos. A associação leva em conta a frequência das palavras e a relação entre os termos. Quanto mais os termos apresentam frequência maior em documentos diferentes, mais probabilidade eles tem de aparecer em novos artigos. Assim, a mineração dos termos calcula a probabilidade de repetição dos termos, com predição de surgimento.

Termo	Taxa de relação (%)
TERMO - "Sarscov"
antibodies	37%
shown	36%
bcl	32%
original	32%
antiapoptotic	31%
apoptosis	31%
bclxl	31%
bhlike	31%
bhmediated	31%
encode	31%
homologs	31%
lymphopenia	31%
prosurvival	31%
rbd	31%
relation	31%
suicide	31%
switch	31%
vaccinecompeting	31%
wired	31%
antagonists	30%
harbored	30%
maintains	30%

Trabalhos sobre cloroquina

04 artigos submetidos cujo termo “chloroquine” aparecem em seus respectivos títulos e/ou palavras-chave.

Submissões sobre Cloroquina
"Combined prophylactic and therapeutic use maximizes hydroxychloroquine anti-SARS-CoV-2 effects in vitro"
"Fatal toxicity of chloroquine or hydroxychloroquine with metformin in mice"
"Azithromycin and ciprofloxacin have a chloroquine-like effect on respiratory epithelial cells"
"Combined prophylactic and therapeutic use maximizes hydroxychloroquine anti-SARS-CoV-2 effects in vitro"

Relação de frequência com os termos "chloroquine"e "vaccine"

A relação entre as frequências das palavras e os termos minerados dos resumos, apresentam porcentagem de repetição e relação. Cada termo relacionado tem uma porcentagem “x%” de ocorrer quando o termos “chloroquine” ou “vaccine” são citados. Isso quer dizer quando o termos “chloroquine aparece, a palavra “opipramol”, por exemplo, tem 58% de chances de aparecer nos resumos submetidos.

Relação entre: frequência de termos x predição de aparecimento do termo
"chloroquine" shortterm - 82% opipramol /pharmacovigilance / prestwick/primum /principle/ provoked - 58% adverse / ampltecamplt / atv / atvrtv/ authorization / azithromycine / bypass - 58 % cautionary/ cellfree/ cleft/ clinics / consuming / docks / eua/ guided - 58% harm / impair /lpv /metformin/ micromolar / motivating /nocere / omeprazol - 58% quinidine /robustness / rtv/ sorted /substances / tnfα /undergoing - 58% virusinduced / warning - 58% hcq - 57% repurposed - 51% toxicity - 49% clinically - 47% approved - 41% antiretroviral/ atazanavir/ bioavailability/documented/ lethality - 40%
"Vaccine" multiepitope - 63% safety - 61% antigenicity - 57% epitopes / immunoinformatics / safe / vaccinology - 50% joined / physicochemical / construct /linkers / adjuvant - 49% antigenic /tlr /dockingmhcii / ifnγ / mhc/ tcell / class / elicit - 48%

Artigos que relacionam a COVID-19 com outras drogas

DocumentTermMatrix (documents: 332, terms: 6285)>>
Non-/sparse entries: 28230/2058390
Sparsity : 99%
Maximal term length: 46

Termo
TERMO - "DRUG"
[1] "The FDA-approved gold drug Auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells"
[2] "Classical drug digitoxin inhibits influenza cytokine storm, with implications for COVID-19 therapy"
[3] "Role of RNA Guanine Quadruplexes in Favoring the Dimerization of SARS Unique Domain in Coronaviruses"
[4] "Reversal of Infected Host Gene Expression Identifies Repurposed Drug Candidates for COVID-19"
[5] "SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles"
[6] "Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease"
[7] "A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing"
[8] "FEP-based screening prompts drug repositioning against COVID-19"
[9] "Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs"
[10] "Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target"
[11] "A data-driven drug repositioning framework discovered a potential therapeutic agent targeting COVID-19"
[12] "Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites"
[13] "Machine intelligence design of 2019-nCoV drugs"
[14] "Potentially highly potent drugs for 2019-nCoV"
[15] "Predicting commercially available antiviral drugs that may act on the novel coronavirus (2019-nCoV), Wuhan, China through a drug-target interaction deep learning model"
[16] "Predictions for the binding domain and potential new drug targets of 2019-nCoV"
[17] "Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19"
[18] "Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design"
[19] "Therapeutic Drugs Targeting 2019-nCoV Main Protease by High-Throughput Screening"

Observatório da ciência foi desenvolvido pelo Laboratório de Informação Científica e Tecnológica em Saúde – LICTS / ICICT / FIOCRUZ

Campus da Fiocruz, Avenida Brasil, 4365 – Pavilhão Haity Moussatché – sala
204, Manguinhos – Rio de Janeiro/ RJ, Tel.: +55 (21) 3865-3245

SCANCOVID-19

BIORXIV

Pesquisas registradas

Quantidade de submissão por data:

Associação de termos - tokens

Trabalhos sobre cloroquina

Relação de frequência com os termos "chloroquine"e "vaccine"

Artigos que relacionam a COVID-19 com outras drogas

Acompanhe conosco os principais dados de covid do Brasil

https://covid.saude.gov.br/

https://bigdata-covid19.icict.fiocruz.br/